Pathology and the anatomical sciences form a bridge between the basic sciences and clinical medicine. Anatomical sciences provide an understanding of the structure and function of the body; pathology provides an understanding of all aspects of human disease. At the University of Missouri, Pathology and Anatomical Sciences is a single academic department encompassing all of these areas.

Faculty in the department teach and conduct research in functional anatomy, histology, cell biology, evolutionary morphology, neuroscience, pathobiology, and laboratory medicine, and practice medicine in anatomic pathology, forensic pathology, and clinical pathology (laboratory medicine).

Our web site has navigation bars on the right to view educational programs, clinical services, and research areas of interest. The divisions of the department are Anatomical Sciences (which includes integrative/functional anatomy and histology), Clinical Pathology (which includes all laboratory testing), Anatomic Pathology (which includes all biopsies and Pap smears), and Forensic Services (including the medical examiner service for Boone and Callaway counties).

If you cannot find something you need, please email or call us using the "Contact Us" button on the right, or below. If you are looking for a prior Newsletter, Grants & Awards notice, or Lab Advances issue, you can browse the Archived Notices. If you have any suggestions or comments, please send them to us by using the Contact Us tab.

News

Dr. Ashley Bartels, lead author of a team led by Pathology and Trauma Surgery in cooperation with Neurosurgery recently won a first place award for a clinical science paper at the Region VII Committee on Trauma, American College of Surgeons, December 2014, Kansas City, Missouri for a study on platelet inhibition in brain trauma.

Dr. Ashley Bartels, a resident in surgery, with Dr. Richard D. Hammer, Director of Hematopathology and Coagulation, and Dr. Sal Ahmad, Director of Surgical ICU, have been studying the use of Thromboelastography (TEG) in traumatic brain injury (TBI) and stroke compared to more traditional methods of coagulation monitoring such as the PFA-100.  PFA-100 is a test that looks for platelet inhibition that may result in prolonged bleeding, and has been commonly used as a replacement for the bleeding time clinically. Having experience with the use of TEG, Dr. Hammer instituted the test at UMH in 2013.

This study was instituted by an observation by Dr. Hammer that victims of trauma and brain injury that resulted in bleeding complications are frequently on antiplatelet drugs for other diseases that was identified on another test, TEG, but often not seen with the PFA-100. This information may not be known at the time of treatment in an emergency and can impact care significantly.

The group studied 475 cases evaluated by PFA over a year and showed that
 PFA-100 results are an unreliable tool to assist in management of TBI and CVA patients. The test resulted in an incorrect assessment in 38% of cases.  A correct assessment of platelet inhibition would have changed neurosurgical management in 98% of those. The lack of identification also resulted in disease exacerbation in 28% of patients.

The paper won first place at the State level ACS Trauma meeting in the summer of 2014 and was selected for a podium presentation at the Regional meeting. The paper will also be published in a upcoming leading trauma journal.

The group is hoping to expand the study to look at the underlying mechanisms of platelet inhibition and brain injury.  Dr. Bartels will now present the findings at the National meeting American College of Surgeons, Committee of Trauma in Las Vegas in March 2015.

Platelet Function Assay—An Unreliable Tool for Detecting Platelet Dysfunction in Traumatic Brain Injuries
Ashley Bartels MD, Yaw Sarpong MD, Jared Coberly MD, Natalie Hughes BS, Scott Litofsky MD, Richard Hammer MD, Stephen L Barnes MD, Salman Ahmad MD

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Mizzou OneHealth Biorepository can now offer tissue along with molecular and histological services.

Check out their web site http://mubiobank.missouri.edu/
The Mizzou One Health Biorepository is a University of Missouri IRB-approved facility for storing and processing de-identified tissue specimens that are not required for diagnostic purposes and would otherwise be discarded.

Their mission is to provide high quality normal and pathologic human tissue samples and ancillary processing services for IRB-approved biomedical research projects. Their inventory currently contains over 2000 paraffin blocks and 1500 frozen tissue aliquots from over 500 benign and malignant specimens.

The vision is to collect tissue and prepare the sample for downstream analytical methods to meet the needs of biomedical researchers, all in one laboratory. After the specimen is retrieved, it is sectioned and stained for a pathologist to review.  DNA or RNA isolations can be performed on either the frozen or paraffin embedded sample and then prepared for further molecular or histological studiesFor additional information regarding specific types of tissue available, and to discuss costs of potential custom or collaborative research projects, please email schnabelj@missouri.edu or contact them through their web site.

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William V. Miller, MD was appointed Vice-Chair for Laboratory Medicine and Departmental Strategic Planning. His significant experience in program development and laboratory administration will be increasingly valuable for future initiatives. He will be responsible for faculty affairs in laboratory medicine, outreach development and strategic planning.

 

 

 

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Archived publications are available as PDF Files.

 

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