Douglas C. Anthony, MD, PhD

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Douglas AnthonyProfessor and Chair
phone: 573-882-8915 (office) 573-884-1938 (lab)
email: anthonydc@missouri.edu
Biographical sketch

Degrees
B.S., Washington University, St. Louis, MO

Ph.D., Duke University, Durham, NC

MD, Duke University, Durham, NC

Additional study
Pathology Residency and Neuropathology Fellowship, Duke University

Academic appointments
Professor/Chair, Pathology and Anatomical Sciences, University of Missouri, Columbia, MO

Professor of Neurology, University of Missouri, Columbia, MO

Director, Tom and Anne Smith MD-PhD Program

Assistant/Associate Professor of Pathology, Harvard Medical School, Boston, MA

Assistant Professor of Pathology & Deputy Medical Examiner, Duke University

Certification: American Board of Pathology - Anatomic pathology (AP) & Neuropathology (NP)

Interests:

  • Functional neuroanatomy
  • Neuropathology, brain tumors
  • Peripheral neuropathy, neuromuscular disease
  • Myopathies
  • Neurotoxicology
  • Neurofilaments, and neuronal cytoskeleton

Research description
Dr. Anthony's laboratory is conducting research in several areas related to the field of neuropathology. A major focus of the laboratory is the pathology of neoplasia, both Medulloblastomas - desmoplastic and classicprimary brain tumors and those that metastasize to the brain. His group's work was the first to define the relationship between the desmoplastic variant of medulloblastoma and the PTCH gene, located on 9q22.3, by recognizing that patients with Gorlin's syndrome (basal cell nevus syndrome) develop this specific variant of medulloblastoma. Studies of astrocytomas have identified karyotypic differences between the pilocytic astrocytoma and the fibrillary astrocytoma. Current ongoing studies are studying the biologic basis for mass spectra in clinical MR spectroscopy, using point-to-point correlation to determine the relationship between biologic features of brain tumors and their spectral characteristics. In collaboration with other MU scientists, the laboratory is working on the progenitor cells of brain tumors that are responsible for their propagation and spread, and the mechanisms of neoplastic growth and metastasis.

The laboratory has also explored the basic pathobiology of intermediate filament accumulation and the relationship between onset of the cytoskeletal alterations and onset of neuropathy. These aggregates of ntermediate filaments occur within axons in a group of toxic disorders and naturally-occurring neurologic diseases. The laboratory is interested in the normal homeostasis of assembly, disassembly, processing, and transport of intermediate filaments, and the alterations that occur in neurologic disease.

Selected Publications

  • Colodner KJ, Montana RA, Anthony DC, Folkerth RD, De Girolami U, Feany MB.  Proliferative potential of human astrocytes.  J Neuropathol Exp Neurol 2005;64:163-9.
  • Marcus KJ, Astrakas LG, Zurakowski D, Zarifi MK, Mintzopoulos D, Poussaint TY, Anthony DC, DeGirolami U, Black PM, Tarbell NJ, Tzika AA. Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers. Internat J Oncol 2007;30:651-7.
  • Johnson KD, Glinskii OV, Mossine VV, Turk JR, Mawhinney TP, Anthony DC, Henry CJ, Huxley VH, Glinsky GV, Peinta KJ, Raz A, Glinskii VV. Galectin-3 as a potential therapeutic target in tumors arising from malignant endothelium. Neoplasia 2007;9:662-70.
  • Bolon B, Anthony DC, Butt M, Dorman D, Green MV, Little PB, Valentine WM, Weinstock D, Yan J, Sills RC.  Current pathology techniques symposium review:  Advances and issues in neuropathology.  Toxicol Sci 2008;36:871-89.
  • Anthony DC, Frosch MP, DeGirolami UL. Peripheral nerve and skeletal muscle. In: Kumar V, Abbas AK, Fausto N, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease, 8th Edition. Philadelphia: Elsevier Saunders, 2010:1257-77.
  • Frosch MP, Anthony DC, DeGirolami UL. The central nervous system. In: Kumar V, Abbas AK, Fausto N, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease, 8th Edition. Philadelphia: Elsevier Saunders, 2010:1279-1344.

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