Charles W. Caldwell, MD, PhD
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CRC Missouri Chair in Cancer Research
Director of Ellis Fischel Cancer Center
Professor of Pathology and Anatomical Sciences
phone: 573-882-8804 (office); 573-884-1344 (lab);
573-817-3741 (pager)
email: caldwellc@missouri.edu
Biographical sketch
Degrees:
BS, Medical Technology, Arkansas State University, Jonesboro, AK
MS, Microbiology, University of Missouri-Columbia
PhD, Microbiology & Immunology, University of Missouri-Columbia
MD, University of Missouri-Columbia
Additional study:
Postdoctoral research in Clinical Pathology (Hematology), University of Missouri-Columbia School of Medicine
Residency, Clinical Pathology, University of Missouri-Columbia School of Medicine
Academic appointments:
Professor of Pathology and Anatomical Sciences, University of Missouri-Columbia School of Medicine
CRC Missouri Chair in Cancer Research (endowed)
Certifications: Clinical Pathology
Interests:
- Epigenetics of hematologic diseases
- Hematopathology
- Cancer pathobiology
Research Description
The laboratory studies epigenetic alterations such as DNA methylation, histone modifications, and Polycomb group proteins involved in tumors such as non-Hodgkin lymphomas and acute/chronic leukemias with the aims of better understanding tumor biology, development of better diagnostic and prognostic biomarkers, and classification of diseases. This is meant to lead to better treatments that target epigenetic alterations in cancer.
Representative Publications
- Shi H, Duff D, Rahmatpanah F, Chitima-Matsiga R, Guo J, Al-Kuhlani M, Taylor KH, Sjahputera O, Andreski M, Wooldridge JE, Caldwell CW. Discovery of Novel Epigenetic Markers in Non-Hodgkin’s Lymphoma. Carcinogenesis 2007;1:60. (Epub June 14, 2006)
- Sjahputera O, Keller JM, Davis JW, Taylor K, Rahmatpanah F, Shi H, Anderson DT, Blisard SN, Luke III RH, Popescu M, Arthur GC, Caldwell CW. Relational Analysis of CpG Islands Methylation and Gene Expression in Human Lymphomas Using Possibilistic C-Means Clustering and Modified Cluster Fuzzy Density. IEEE Transactions on Computational Biology and Bioinformatics, 2007:4; 178 – 189.
- Taylor KH, Pena-Hernandez KE, Davis JW, Arthur GL, Duff DJ, Shi H, Rahmatpanah FB, Sjahputera O, Caldwell CW. Large-scale analysis of the acute lymphoblastic leukemia methylome. Cancer Res, 2007:67;2617 – 2625.
- Bryan JN, Keeler MR, Henry CJ, Bryan ME, Hahn AW, Caldwell CW: A population study of neutering status as a risk factor for canine prostate cancer. Prostate, 2007: 67;1164-1181.
- Taylor KH, Kramer RS, Davis JW, Guo J, Duff DJ, Xu D, Caldwell CW, Shi H: Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing. Can Res 2007:67; 8511-8518.
- Shi H, Wang MX, Caldwell CW: CpG islands - their potential as biomarkers for cancer. Expert Rev Molecular Diagnostics 2007;7:519-531.
- Taylor KH, Rahmatpanah F, Davis JW, Caldwell CW: Chromosomal localization of DNA methylation in follicular lymphoma. Leukemia (Epub Aug 30, 2007).
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