Vladislav Glinskii, MD
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Assistant Professor
phone: 573-814-6000, 53691
email: glinskiivl@missouri.edu
Biographical sketch
Degrees: MD, State Medical Institute, Chernovtsy, Ukraine
Additional study: Residency, R.E. Kavetsky Institute of Oncology Problems, Ukrainian National Academy of Sciences; Fellowship, Biochemistry, University of Missouri-Columbia
Academic appointments: Post-doctoral fellow, University of Missouri; Research Scientist, Ukrainian National Academy of Sciences; Research Scientist, Harry S Truman Veterans Administration Medical Center
Certifications:
Interests:
- Cancer biology
- Mechanisms of metastasis
- Cell-cell adhesion in cancer metastasis
Research description: Molecular mechanisms of cancer metastasis. Metastatic cancer cell interactions with microvascular endothelium. Biochemistry of cancer cell recognition and adhesion. Microvascular pathophysiology of hematogenous cancer metastiasis. Antimetastatic drug design and testing. Molecular mechanisms of regulation and execution of apoptosis (programmed cell death) in metastatic cancer cells. Telomeredependent control of apoptosis. Structural-functional characterization of humon telomerase ribonucleoprotein complex.
Representative Publications:
Glinsky, V.V., Kiriakova, G., Glinskii, O.V., Mossine, V.V., Mawhinney, T.P. Turk, J.R., Glinskii, A.B., Huxley, V.H., Price, J.E., Glinsky, G.V. Synthetic Galectin-3 Inhibitor Increases Metastatic Cancer Cell Sensitivity to Taxol-Induced Apoptosis In Vitro and In Vivo. Neoplasia, 11: 901-909, 2009.
Johnson, K.D., Glinskii, O.V., Mossine, V.V., Turk, J.R., Mawhinney, T.P., Anthony, D.C., Henry, C.J., Huxley, V.H., Glinsky, G.V., Pienta, K.J., Raz, A., and Glinsky, V.V. Galectin-3 as a Potential Therapeutic Target in Tumors Arising from Malignant Endothelium. Neoplasia, 9: 662-670, 2007.
Glinsky, V.V. Intravascular cell-to-cell adhesive interactions and bone metastasis. Cancer and Metastasis Reviews, 25: 531-540, 2006.
Glinskii, O.V., Huxley, V.H., Glinsky, G.V., Pienta, K.J., Raz, A., and Glinsky, V.V. Mechanical Entrapment Is Insufficient and Intercellular Adhesion Is Essential for Metastatic Cell Arrest in Distant Organs. Neoplasia, 7: 522-527, 2005.
Glinskii, O.V., Turk, J.R., Pienta, K.J., Huxley, V.H., and Glinsky, V.V. Evidence of Porcine and Human Endothelium Activation by Cancer-Associated Carbohydrates Expressed on Glycoproteins and Tumor Cells. J. Physiol. ( London), 554:89-99, 2004.
Glinsky, V.V., Glinsky, G.V., Glinskii, O.V., Huxley, V.H. Turk, J.R., Mossine, V.V., Deutscher, S.L., Pienta, K.J., and Quinn, T.P. Intravascular Metastatic Cancer Cell Homotypic Aggregation at the Sites of Primary Attachment to the Endothelium. Cancer Research, 63: 3805-3811, 2003.
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