Michael X. Wang, MD, PhD
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Assistant Professor
Director of Diagnostic Molecular Pathology Laboratory
phone: 573-882-1276
email: wangmx@missouri.edu
Degrees:
MS, Medical Microbiology, Peking Union Medical College/Chinese Academy of Preventive Medicine
MD, Lanzhou University, Lanzhou Medical College, Lanzhou, China
PhD, Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio, TX
Additional study:
Residency, UCLA – Harbor Medical Center and University of Hawaii School of Medicine – Clinical & Anatomic Pathology
Fellowship, The University of New Mexico Health Science Center, Hematopathology
Fellowship, The University of Arizona Health Science Center, Molecular Genetic Pathology
Academic appointments:
Assistant Professor of Pathology
Clinical Pathologist
Director of Diagnostic Molecular Pathology Laboratory
Certifications: Clinical Pathology; Hematology in Pathology; Molecular Genetic Pathology
Interests:
- Diagnostic hematopathology, Molecular mechanisms of leukemia and lymphoma
- Diagnostic molecular pathology, Molecular detection of residual cancer cells and pathogens
Research description
Dr. Wang’s research focus is translational study to develop new molecular diagnostic tests for residual tumor cell and pathogen detection. By utilizing the specific DNA methylation biomarkers, he developed a nested PCR-based molecular method which could detect 1 tumor cell allele in 1 million normal cell alleles. This method can potentially be used in cancer screening and early detection, cancer therapeutic monitoring, and minimal residual disease detection, and thus, prognostic prediction. He is also interested in molecular interactions between genetic and epigenetic systems in tumor stem cells during tumorigenesis especially leukemogenesis and lymphomagenesis.
Representative Publications
- Wang, MX, Wang HY, Zhao XH, Nalluri S, Wang HY, Ning J, Duff D, Taylor KH, Gruner BA, Shi H, and Caldwell CW (2009): Molecular Detection of B-cell Neoplasia by Specific DNA Methylation (in submission)
- Duff, DJ, Nalluri, S, and Wang, MX (2009): Promoter CGI Methylation of Reprogramming Factors in Aggressive B-cell Lymphomas. AACR Proceeding Supplement: Late-Breaking Abstracts, LB166
- Wang, MX and Shi, HD (2009): Basics of Molecular Biology, Genetic Engineering and Metabolic Engineering, Chapter 2 in: Fu, PC and Panke, S (ed): Systems Biology and Synthetic Biology, John Wiley & Brothers, Inc., pp9-66.
- Wang, MX, Zhao XH, Nalluri S, Wang HY, Taylor KH, Shi H, and Caldwell CW (2008): A Sensitive Molecular Method for Detection of Disseminating Hematopoietic Tumor Cells by Using Specific Epigenetic DNA Methylation Biomarkers. Blood 112 (Abstract 4850).
- Wang, MX, Shi HD, Zhao, XH, Taylor, KH, Duff, D and Caldwell CW (2007): Molecular Detection of Residual Leukemic Cells by a Novel DNA Methylation Biomarker (Abstract #1206), Modern Pathology 20 (supplement 2): 263A.
- Shi HD, Wang, MX, and Caldwell CW (2007): CpG islands: their potential as biomarkers for cancer. Expert Rev. Mol. Diagn. 7(5): 519-531.
- Wang, MX, Duff, D., Shi, H., Taylor, KH., Gruner BA., and Caldwell, CW. (2005): Detection of Minimal Residual Disease in Precursor B Lymphoblastic Leukemia (B-ALL) Patients by a Novel Epigenetic DNA Methylation Biomarker, Blood, 106 (Abstract #4524).
- Wang, X. and Martin LA (2003): Regulation of insulin-like growth factor-I gene expression. In: LeRoith D., Zumkeller, W., and Baxter, R. C., Eds, Insulin-like Growth Factors. New York, NY: Kluwer Academic/Plenum Publishers, pp 64-9.
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