Michael X. Wang, MD, PhD

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Michael WangAssociate Professor
Director of Molecular Pathology Laboratory
Director of HLA Laboratory
phone: 573-882-1276
email: wangmx@missouri.edu

Biographical sketch

Degrees:
MS, Medical Microbiology, Peking Union Medical College/Chinese Academy of Preventive Medicine, Beijing, China

MD, Lanzhou University, Lanzhou Medical College, Lanzhou, China

PhD, Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio, TX

Additional study:
Residency, UCLA – Harbor Medical Center and University of Hawaii School of Medicine – Clinical & Anatomic Pathology

Fellowship, the University of New Mexico Health Science Center, Hematopathology

Fellowship, the University of Arizona Health Science Center, Molecular Genetic Pathology

Academic appointments:
Associate Professor of Pathology

Clinical Pathologist

Director of Molecular Pathology Laboratory

Director of HLA Laboratory

Certifications: Clinical Pathology; Hematology in Pathology; Molecular Genetic Pathology

Interests:

  • Diagnostic hematopathology, Molecular mechanisms of leukemia and lymphoma
  • Diagnostic molecular pathology, Molecular detection of residual cancer cells and pathogens
  • Next generation sequencing, genomic medicine, interaction of genetics and epigenetics in cancer

Research description
Dr. Wang’s research focus is translational study to develop new molecular diagnostic tests for residual tumor cell and pathogen detection. By utilizing specific genetic and epigenetic biomarkers including mutations, DNA methylation and microRNA, he developed a PCR-based molecular method which could detect 1 tumor cell in 1 million normal cells. This method can potentially be used in cancer screening and early detection, cancer therapeutic monitoring, and minimal residual disease detection. He is also interested in molecular interactions between genetic, epigenetic and metabolic systems during tumorigenesis especially in leukemogenesis, lymphomagenesis and lung cancer.

Representative Publications

  • Kang I, Wang Y, Reagan C, Fu Y, Wang MX, Gu LQ (2013): Single-molecule epigenetic sequencing with an interstrand lock. Scientific Reports from Nature Publishing Group, In press.
  • Regunath H, Shortridge J, Raza S, Huffman BM, Wang MX and Xiang D (2013): The occult pulmonary MALT lymphoma presenting as catastrophic anti-phospholipid antibody syndrome. Oncology Letters, In press.
  • Kern JB, Duff DJ, Odem JL, Esebua M, Lisa R. Smith LR, Doll D, and Wang MX (2013): A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma. Case Rep Pathol. 2013:784176. Epub 2013 Feb 12.
  • Gu LQ, Wanunu M, Wang MX, McReynolds L and Wang Y (2012): Detection of miRNAs with a nanopore single-molecule counter. Expert Reviews for Molecular Diagnostics. Expert Rev Mol Diagn. 2012;12(6):573-84.
  • Wang L, Wang J, Wang MX, Li Y, Liang Y, Xu D (2012): Using Internet Search Engines to Obtain Medical Information: A Comparative Study.  J Med Internet Res 14(3), e74
  • Kristen H. Taylor and Michael X. Wang (2012): DNA Methylation in Acute Leukemia, InTech - Open Access Publisher, pp 359-386
  • Wang Y, Zheng D, Tan Q, Wang MX and Gu LQ (2011): Nanopore based detection of circulating microRNA in lung cancer patients. Nature Nanotechnology 6(10):668-74.
  • Zheng D, Haddadin S, Wang Y, Gu LQ, Perry MC, Freter CE, and Wang MX (2011): Plasma MicroRNAs as Novel Biomarkers for Early Detection of Lung Cancer, Int J Clin Exp Pathol;4:575-586.
  • Wang, MX and Shi, HD (2009): Basics of Molecular Biology, Genetic Engineering and Metabolic Engineering, Chapter 2 in: Fu, PC and Panke, S (ed): Systems Biology and Synthetic Biology, John Wiley & Brothers, Inc., pp9-66.
  • Wang MX, Wang HY, Zhao XH, Nalluri S, Zheng DL, Ning J, Duff D, Taylor KH, Gruner BA, Shi H, and Caldwell CW (2010): Molecular Detection of B-cell Neoplasia by Specific DNA Methylation Biomarkers, Int J Clin Exp Pathol;3: 265-279.
  • Shi HD, Wang MX and Caldwell CW (2007): CpG islands: Their Potential as Biomarkers for Cancer. Expert Rev. Mol. Diagn. 7: 1-13.

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